Veld grape (Cissus quadrangularis ) is an under-the-radar plant extract gaining traction for its metabolic benefits. Traditionally used in African and Asian medicine for bone health and injury recovery, modern research highlights its potential to support appetite control, body composition, blood sugar balance, and even blood pressure.
How Veld Grape Works
Metabolism isn’t just about burning calories; it’s the complex process of turning food into energy, managing blood sugar, and regulating appetite. Veld grape impacts these processes through several pathways.
1. Appetite Regulation: Studies show veld grape increases GLP-1, a hormone that promotes fullness, and reduces DPP-4, an enzyme that breaks down GLP-1. This translates to lower calorie intake and improved satiety.
2. Body Composition: Clinical trials demonstrate significant reductions in body weight, body fat percentage, and waist/hip circumference with veld grape supplementation. A study using 300mg of a standardized extract showed up to 12.8% body fat reduction in 8 weeks—even without dietary or exercise changes.
3. Blood Sugar & Cholesterol: Veld grape may improve fasting blood glucose, triglycerides, and total cholesterol levels. Research indicates reductions in total cholesterol and increases in HDL (“good”) cholesterol.
4. Blood Pressure Support: Studies suggest veld grape extract can effectively lower both systolic and diastolic blood pressure.
5. AMPK Activation: At a cellular level, veld grape activates AMPK, a key enzyme regulating energy balance. AMPK promotes fat oxidation, improves insulin sensitivity, and boosts fuel efficiency.
6. Digestive Support: Preclinical research indicates that veld grape may influence enzymes involved in breaking down fats and carbohydrates. This can support more balanced digestion without blocking nutrient absorption.
Dosage & Application
Most human studies use around 300mg per day of a standardized Cissus quadrangularis extract, such as CQR-300®. This dosage is associated with improvements in appetite, body composition, and metabolic markers. Some supplements combine veld grape with other ingredients like creatine to enhance muscle building and strength.
Veld grape is not a magic bullet but a potentially valuable tool for supporting metabolic health and lean muscle mass as part of a comprehensive approach including diet, exercise, and stress management.
For those seeking to optimize metabolic function and body composition, veld grape is an extract worth considering. Consult with a healthcare provider before starting any new supplement regimen, especially if pregnant, breastfeeding, or taking medications.
